1H-Pyrazole-4-carbonyl chloride

Base Information

• Chemical Name: 1H-Pyrazole-4-carbonyl chloride
• CAS No.: 103286-53-9
• Molecular Formula: C4H3ClN2O
• Molecular Weight: 130.53200
• Hs Code.: 2933199090
• Mol file: 103286-53-9.mol

Synonyms:1H-pyrazole-4-carbonyl chloride;.4-pyrazolecarbonyl chloride;

Chemical Property of 1H-Pyrazole-4-carbonyl chloride

Chemical Property:

• PSA: 45.75000
• LogP: 0.78870

Purity/Quality:

98%min ^*data from raw suppliers

1H-Pyrazole-4-carbonyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-4-carbonyl chloride

There total 1 articles about 1H-Pyrazole-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1H-pyrazole-4-carboxylic acid (37718-11-9) → 1H-pyrazole-4-carboxylic acid chloride (103286-53-9)

Guidance literature:

With thionyl chloride; for 18h; Heating / reflux;

Reference yield: 80.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + 1H-pyrazole-4-carboxylic acid chloride (103286-53-9) → 4-(1H-pyrazole-4-carboxamido)benzoic acid

Guidance literature:

4-amino-benzoic acid; With dmap; In N,N-dimethyl acetamide; at 80 ℃; for 0.5h; Inert atmosphere;

1H-pyrazole-4-carboxylic acid chloride; With pyridine; In N,N-dimethyl acetamide; at 10 - 40 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejic.201701290

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + 1H-pyrazole-4-carboxylic acid chloride (103286-53-9) → morpholino(1H-pyrazol-4-yl)methanone (1152749-21-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.2h;

upstream raw materials:

1H-pyrazole-4-carboxylic acid

Downstream raw materials:

morpholino(1H-pyrazol-4-yl)methanone

Refernces

• 1、 -. "DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES". Page/Page column 39; 268-269. . Retrieved 2020/01/24.
• 2、 -. "PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME". Paragraph 00190. . Retrieved 2017/07/14.