Pyrrolidine, 1-(oxophenylacetyl)-

Base Information

• Chemical Name: Pyrrolidine, 1-(oxophenylacetyl)-
• CAS No.: 103383-80-8
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241
• Mol file: 103383-80-8.mol

Synonyms:

Chemical Property of Pyrrolidine, 1-(oxophenylacetyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-(oxophenylacetyl)-

There total 39 articles about Pyrrolidine, 1-(oxophenylacetyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pyrrolidine (123-75-1) + 1-phenyl-2-hydroxyethanone (582-24-1) → 1-phenyl-2-(pyrrolidin-1-yl)ethane-1,2-dione (103383-80-8)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In acetonitrile; at 20 ℃; for 4h; Green chemistry;

DOI:10.1016/j.tetlet.2015.09.053

Reference yield: 89.0%

pyrrolidine (123-75-1) + 3-phenyl-propionaldehyde (104-53-0) → 1-phenyl-2-(pyrrolidin-1-yl)ethane-1,2-dione (103383-80-8)

Guidance literature:

With oxygen; copper diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 6h; Green chemistry;

DOI:10.1016/j.tetlet.2020.152555

Reference yield: 89.0%

pyrrolidine (123-75-1) + acetophenone (98-86-2) → 1-phenyl-2-(pyrrolidin-1-yl)ethane-1,2-dione (103383-80-8)

Guidance literature:

With N-iodo-succinimide; oxygen; In ethanol; at 20 ℃; for 32h; Catalytic behavior; Green chemistry;

DOI:10.1016/j.catcom.2019.105806

upstream raw materials:

pyrrolidine

phenylglyoxal hydrate

iodobenzene

carbon monoxide

Downstream raw materials:

3-hydroxy-3-phenylhex-5-en-2-one

Refernces

• 1、 Urbán, Béla,Papp, Máté,Srankó, Dávid,Skoda-F?ldes, Rita. "Phosphine-free atmospheric carbonylation of aryl iodides with aniline derivatives in the presence of a reusable silica-supported palladium catalyst". . p. 150 - 157. Retrieved 2015.
• 2、 Zhou, Chao,Diao, Pinhui,Li, Xiaoji,Ge, Yanqin,Guo, Cheng. "Facile photochemical synthesis of α-ketoamides and quinoxalines from amines and benzoylacetonitrile under mild conditions". . p. 371 - 374. Retrieved 2019.
• 3、 Mei, Hui,Hu, Jianglin,Xiao, Se,Lei, Yizhu,Li, Guangxing. "Palladium-1,10-phenanthroline complex encaged in y zeolite: An efficient and highly recyclable heterogeneous catalyst for aminocarbonylation". . p. 40 - 47. Retrieved 2014.
• 4、 Kotha, Surya Srinivas,Chandrasekar, Selvaraj,Sahu, Samrat,Sekar, Govindasamy. "IronO-Catalyzed Domino Aerobic Alcohol Oxidation/Oxidative Cross-Dehydrogenative Coupling for the Synthesis of α-Keto Amides". . p. 7451 - 7457. Retrieved 2014.
• 5、 Nekkanti, Shalini,Veeramani, Karuna,Praveen Kumar, Niggula,Shankaraiah, Nagula. "Microwave-assisted direct oxidative synthesis of α-ketoamides from aryl methyl ketones and amines by a water soluble Cu(i)-complex". . p. 3439 - 3447. Retrieved 2016.
• 6、 Kotha, Surya Srinivas,Sekar, Govindasamy. "Metal free synthesis of α-keto amides from 2-hydroxy acetophenones through domino alcohol oxidation-oxidative amidation reaction". . p. 6323 - 6326. Retrieved 2015.
• 7、 Yang, Shu-Qing,Yao, Yin-Qing,Chen, Xiao-Chao,Lu, Yong,Zhao, Xiao-Li,Liu, Ye. "Pd-Catalyst Containing a Hemilabile P,C-Hybrid Ligand in Amino Dicarbonylation of Aryl Halides for Synthesis of α-Ketoamides". . p. 1032 - 1041. Retrieved 2021/05/07.
• 8、 -. "Preparation method of alpha-carbonyl amide compound". Paragraph 0146-0149. . Retrieved 2021/08/14.