2-FLUORO-3-HYDROXYBENZALDEHYDE

Base Information

• Chemical Name: 2-FLUORO-3-HYDROXYBENZALDEHYDE
• CAS No.: 103438-86-4
• Molecular Formula: C7H5FO2
• Molecular Weight: 140.114
• Hs Code.: 2913000090
• Mol file: 103438-86-4.mol

Synonyms:2-fluoro-3-hydroxybenzaldehyde;

Chemical Property of 2-FLUORO-3-HYDROXYBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0685mmHg at 25°C
• Melting Point: 112-113℃
• Boiling Point: 222.4oC at 760 mmHg
• Flash Point: 88.3oC
• PSA: 37.30000
• Density: 1.35g/cm3
• LogP: 1.34380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-3-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-3-HYDROXYBENZALDEHYDE

There total 6 articles about 2-FLUORO-3-HYDROXYBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(tert-Butyl-dimethyl-silanyloxy)-2-fluoro-benzaldehyde (113984-69-3) → 2-fluoro-3-hydroxybenzaldehyde (103438-86-4)

Guidance literature:

With potassium fluoride; hydrogen bromide; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

DOI:10.1055/s-1988-27681

Reference yield: 79.0%

2-fluoro-3-methoxybenzaldehyde (103438-88-6) → 2-fluoro-3-hydroxybenzaldehyde (103438-86-4)

Guidance literature:

With boron tribromide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00160a030

Reference yield:

3-methoxy-2-nitrobenzaldehyde dimethyl acetal → 2-fluoro-3-hydroxybenzaldehyde (103438-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, Et₃N / PtO₂ / methanol

2: 1.) HBF₄, sodium nitrite / 1.) H₂O, -4 deg C, overnight, 2.) H₂O, irradiation, 5-10 deg C, 4 h

3: 79 percent / BBr₃ / CH₂Cl₂ / Ambient temperature

With tetrafluoroboric acid; hydrogen; boron tribromide; triethylamine; sodium nitrite; platinum(IV) oxide; In methanol; dichloromethane;

DOI:10.1021/jm00160a030

upstream raw materials:

3-(tert-Butyl-dimethyl-silanyloxy)-2-fluoro-benzaldehyde

N,N-dimethyl-formamide

tert-Butyl-(2-fluoro-phenoxy)-dimethyl-silane

2-fluoro-3-methoxybenzaldehyde

Downstream raw materials:

3-acetoxy-2-fluorobenzaldehyde

3-(cyclohexylmethoxy)-2-fluorobenzaldehyde

Refernces

• 1、 Kawatkar, Sameer P.,Keating, Thomas A.,Olivier, Nelson B.,Breen, John N.,Green, Oluyinka M.,Guler, Satenig Y.,Hentemann, Martin F.,Loch, James T.,McKenzie, Andrew R.,Newman, Joseph V.,Otterson, Linda G.,Martínez-Botella, Gabriel. "Antibacterial inhibitors of gram-positive thymidylate kinase: Structure-activity relationships and chiral preference of a new hydrophobic binding region". . p. 4584 - 4597. Retrieved 2014/07/07.
• 2、 -. "Novel Dosage Form". Paragraph 0272; 0273. . Retrieved 2014/09/03.