21-Dehydro DexaMethasone

Base Information

• Chemical Name: 21-Dehydro DexaMethasone
• CAS No.: 2964-79-6
• Molecular Formula: C₂₂H₂₇FO₅
• Molecular Weight: 390.452
• Mol file: 2964-79-6.mol

Synonyms:

Chemical Property of 21-Dehydro DexaMethasone

Chemical Property:

• Melting Point: >175°C (dec.)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

21-DehydroDexamethasoneHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 21-Dehydro Dexamethasone is an impurity of Dexamethasone (D298800), a glucocorticoid anti-inflammatory agent.

Technology Process of 21-Dehydro DexaMethasone

There total 3 articles about 21-Dehydro DexaMethasone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

dexamethasone (50-02-2) → dexamethasone glyoxal (2964-79-6)

Guidance literature:

With copper diacetate; oxygen; In methanol; for 0.583333h; Ambient temperature;

DOI:10.1016/0223-5234(91)90137-C

Reference yield:

methanol (67-56-1) + dexamethasone (50-02-2) → dexamethasone glyoxal (2964-79-6) + 11β,17α-dihydroxy-9α-fluoro-16α-methyl-3,20-dioxo-1,4-pregnadien-21-al methyl hemiacetal

Guidance literature:

With copper diacetate; air; for 1.5h; Title compound not separated from byproducts.;

DOI:10.1021/jo020282g

Reference yield:

→ dexamethasone glyoxal (2964-79-6)

Guidance literature:

upstream raw materials:

dexamethasone

methanol

Downstream raw materials:

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid

Refernces

• 1、 Conrow, Raymond E.,Dillow, Glen W.,Bian, Liangqiao,Xue, Liang,Papadopoulou, Olga,Baker, John K.,Scott, Britt S.. "Corticosteroid decomposition via a mixed anhydride". . p. 6835 - 6836. Retrieved 2007/10/03.
• 2、 Milioni, C,Jung, L,Koch, B. "Synthesis of new local anti-inflammatory thiosteroids based on antedrug concept". . p. 947 - 951. Retrieved 2007/10/02.