Technology Process of (Z)-3-(2-Azido-phenyl)-acrylonitrile
There total 3 articles about (Z)-3-(2-Azido-phenyl)-acrylonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaH / dimethylformamide / 0.08 h / ice cooling
2: H2 / 10 percent palladium/charcoal / methyl acetate
3: 1) aqueous sodium nitrite, 2) sodium azide / 1) 1N aqueous hydrochloric acid, ice cooling; 2) pH 5, 30 min
With
sodium azide; hydrogen; sodium hydride; sodium nitrite;
palladium on activated charcoal;
In
acetic acid methyl ester; N,N-dimethyl-formamide;
DOI:10.1021/jo01311a044
- Guidance literature:
-
Multi-step reaction with 2 steps
1: H2 / 10 percent palladium/charcoal / methyl acetate
2: 1) aqueous sodium nitrite, 2) sodium azide / 1) 1N aqueous hydrochloric acid, ice cooling; 2) pH 5, 30 min
With
sodium azide; hydrogen; sodium nitrite;
palladium on activated charcoal;
In
acetic acid methyl ester;
DOI:10.1021/jo01311a044
- Guidance literature:
-
With
sodium azide; sodium nitrite;
Yield given. Multistep reaction;
1) 1N aqueous hydrochloric acid, ice cooling; 2) pH 5, 30 min;
DOI:10.1021/jo01311a044