2,6-Dichloro-4-phenylquinoline

Base Information

• Chemical Name: 2,6-Dichloro-4-phenylquinoline
• CAS No.: 10352-30-4
• Molecular Formula: C15H9Cl2N
• Molecular Weight: 274.149
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID70401944
• Wikidata: Q82205264
• Mol file: 10352-30-4.mol

Synonyms:2,6-dichloro-4-phenylquinoline;10352-30-4;Quinoline, 2,6-dichloro-4-phenyl-;ChemDiv3_000673;SCHEMBL11826284;DTXSID70401944;FSVNVFMEUXPATP-UHFFFAOYSA-N;HMS1474O13;AKOS001276597;SB70587;NCGC00172633-01;EU-0001018;EN300-88883;SR-01000395981;SR-01000395981-1;BRD-K76137601-001-01-5;F0016-0970;Z207210374

Chemical Property of 2,6-Dichloro-4-phenylquinoline

Chemical Property:

• Melting Point: 114-115 °C
• Boiling Point: 399.0±42.0 °C(Predicted)
• PSA: 12.89000
• Density: 1.331±0.06 g/cm3(Predicted)
• LogP: 5.20860
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 273.0112047
• Heavy Atom Count: 18
• Complexity: 278

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,6-Dichloro-4-phenylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=NC3=C2C=C(C=C3)Cl)Cl

Technology Process of 2,6-Dichloro-4-phenylquinoline

There total 9 articles about 2,6-Dichloro-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-Chlor-1,2-dihydro-4-phenylchinolin-2-on (30169-33-6) → 2,6-dichloro-4-phenylquinoline (10352-30-4)

Guidance literature:

With trichlorophosphate;

DOI:10.1248/cpb.28.2618

Reference yield: 62.0%

→ 2,6-dichloro-4-phenylquinoline (10352-30-4)

Guidance literature:

Reference yield:

6-chloro-4-phenyl-2-quinolinone (30169-33-6) → 2,6-dichloro-4-phenylquinoline (10352-30-4)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01160a522

upstream raw materials:

6-chloro-4-phenyl-2-quinolinone

6-Chlor-1,2-dihydro-4-phenylchinolin-2-on

N-(2-benzoyl-4-chlorophenyl)acetamide

5-chloro-2-aminobenzophenone

Downstream raw materials:

6-Chlor-2-(2-hydroxyethylamino)-4-phenylchinolin

6-Chlor-2-dimethylamino-4-phenylchinolin

2-(2-Diethylaminoethylamino)-6-chlor-4-phenylchinolin

6-chloro-2-hydrazino-4-phenylquinoline

Refernces

• 1、 Guan, Li-Ping,Jin, Qing-Hao,Wang, Shou-Feng,Li, Fu-Nan,Quan, Zhe-Shan. "Synthesis and anticonvulsant activity of 5-phenyl-[1,2,4]-triazolo[4,3-a] quinolines". scheme or table. p. 774 - 779. Retrieved 2009/04/14.
• 2、 -. "2-[3-(Phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenones". . . Retrieved 2008/06/13.