4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol

Base Information

• Chemical Name: 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol
• CAS No.: 86485-24-7
• Molecular Formula: C₁₉H₂₂FNO₃
• Molecular Weight: 331.387
• Mol file: 86485-24-7.mol

Synonyms:

Chemical Property of 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol

There total 4 articles about 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ethyl ester (112434-95-4) → 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol (86485-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 2N aq. NaOH / ethanol / 3 h / Heating

2: aq. HCl / ethanol / 2.5 h / Heating

3: 1) Mg / 1) I₂ / 1) ether, reflux, 30 min, 2) ether, reflux, 3 h

With hydrogenchloride; sodium hydroxide; magnesium; iodine; In ethanol;

DOI:10.1002/jhet.5570240336

Reference yield:

6,7-Dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid → 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol (86485-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / ethanol / 2.5 h / Heating

2: 1) Mg / 1) I₂ / 1) ether, reflux, 30 min, 2) ether, reflux, 3 h

With hydrogenchloride; magnesium; iodine; In ethanol;

DOI:10.1002/jhet.5570240336

Reference yield:

N-(2-carboethoxy-4,5-dimethoxybenzyl)sarcosine methyl ester (112434-97-6) → 4-(2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-4(1H)-isoquinolinol (86485-24-7)

Guidance literature:

Multi-step reaction with 4 steps

1: C₂H₅ONa / benzene / 80 °C

2: 2N aq. NaOH / ethanol / 3 h / Heating

3: aq. HCl / ethanol / 2.5 h / Heating

4: 1) Mg / 1) I₂ / 1) ether, reflux, 30 min, 2) ether, reflux, 3 h

With hydrogenchloride; sodium hydroxide; sodium ethanolate; magnesium; iodine; In ethanol; benzene;

DOI:10.1002/jhet.5570240336

upstream raw materials:

6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-4-isochinolon

2-fluorobenzyl chloride

6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ethyl ester

N-(2-carboethoxy-4,5-dimethoxybenzyl)sarcosine methyl ester

Refernces