edatrexate (2-13C-glutamate) diethyl ester

Base Information

• Chemical Name: edatrexate (2-13C-glutamate) diethyl ester
• CAS No.: 188404-13-9
• Molecular Formula: C₂₆H₃₃N₇O₅
• Molecular Weight: 524.581
• Mol file: 188404-13-9.mol

Synonyms:

Chemical Property of edatrexate (2-13C-glutamate) diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of edatrexate (2-13C-glutamate) diethyl ester

There total 1 articles about edatrexate (2-13C-glutamate) diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoic acid (80576-81-4) + diethyl 2-13C-L-glutamate hydrochloride → edatrexate (2-13C-glutamate) diethyl ester (188404-13-9)

Guidance literature:

With benzotriazole oxophosphonate; triethylamine; Yield given. Multistep reaction; 1.) DMF, RT, 1.5 h, 2.) DMF, RT, 20 h;

DOI:10.1002/(SICI)1099-1344(199702)39:2<99::AID-JLCR949>3.0.CO;2-#

Reference yield: 44.0%

edatrexate (2-13C-glutamate) diethyl ester (188404-13-9) → edatrexate (2-13C-glutamic acid)

Guidance literature:

With sodium hydroxide; In 2-methoxy-ethanol; for 2.75h; Ambient temperature;

DOI:10.1002/(SICI)1099-1344(199702)39:2<99::AID-JLCR949>3.0.CO;2-#

upstream raw materials:

4-[1-(2,4-Diamino-pteridin-6-ylmethyl)-propyl]-benzoic acid

Refernces