9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE

Base Information

• Chemical Name: 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE
• CAS No.: 477886-49-0
• Molecular Formula: C₂₄H₁₉ClN₂O₂
• Molecular Weight: 402.88
• Mol file: 477886-49-0.mol

Synonyms:

Chemical Property of 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE

Chemical Property:

• Boiling Point: 611.8±55.0 °C(Predicted)
• PKA: -2.40±0.40(Predicted)
• Density: 1.40±0.1 g/cm3(Predicted)

Purity/Quality:

9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE

There total 3 articles about 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-benzoyl chloride (874-60-2) + 9b-(p-chlorophenyl)-1,2,3,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one (6038-49-9) → C24H19ClN2O2 (477886-49-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm4013246

Reference yield:

2-(4-chlorobenzoyl)benzoic acid (85-56-3) → C24H19ClN2O2 (477886-49-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Dean-Stark; Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1021/jm4013246

Reference yield:

→ C24H19ClN2O2 (477886-49-0)

Guidance literature:

upstream raw materials:

4-methyl-benzoyl chloride

9b-(p-chlorophenyl)-1,2,3,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one

2-(4-chlorobenzoyl)benzoic acid

Refernces

• 1、 -. "POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS". Page/Page column 47. . Retrieved 2010/02/12.