Z-D-Nva-ONB

Base Information

• Chemical Name: Z-D-Nva-ONB
• CAS No.: 80384-00-5
• Molecular Formula: C₂₂H₂₄N₂O₆
• Molecular Weight: 412.442
• Mol file: 80384-00-5.mol

Synonyms:

Chemical Property of Z-D-Nva-ONB

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-D-Nva-ONB

There total 1 articles about Z-D-Nva-ONB which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-hydroxy-5-norbornene-2,3-dicarboximide (21715-90-2) + (R)-2-(N-benzyloxycarbonylamino)pentanoic acid (42918-89-8) → Z-D-Nva-ONB (80384-00-5)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1248/cpb.29.3646

Reference yield: 80.0%

N-[(S)-2-(N'-Acetyl-hydrazino)-1-benzyl-2-oxo-ethyl]-2-amino-acetamide (74086-19-4) + Z-D-Nva-ONB (80384-00-5) → [(R)-1-({[(S)-2-(N'-Acetyl-hydrazino)-1-benzyl-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-butyl]-carbamic acid benzyl ester (74086-20-7)

Guidance literature:

In N,N-dimethyl-formamide; for 10h; Ambient temperature;

DOI:10.1248/cpb.29.3646

Reference yield:

Z-D-Nva-ONB (80384-00-5) → (R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-pentanoic acid {[(S)-2-(N'-acetyl-hydrazino)-1-benzyl-2-oxo-ethylcarbamoyl]-methyl}-amide (73976-43-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / dimethylformamide / 10 h / Ambient temperature

2: hydrogen / Pd-black / methanol / Ambient temperature

3: dimethylformamide / 10 h / Ambient temperature

4: 160 mg / hydrogen / Pd-black / methanol / Ambient temperature

With hydrogen; palladium; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.29.3646

upstream raw materials:

N-hydroxy-5-norbornene-2,3-dicarboximide

(R)-2-(N-benzyloxycarbonylamino)pentanoic acid

Downstream raw materials:

[(R)-1-({[(S)-2-(N'-Acetyl-hydrazino)-1-benzyl-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-butyl]-carbamic acid benzyl ester

(R)-2-Amino-pentanoic acid {[(S)-2-(N'-acetyl-hydrazino)-1-benzyl-2-oxo-ethylcarbamoyl]-methyl}-amide

(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-pentanoic acid {[(S)-2-(N'-acetyl-hydrazino)-1-benzyl-2-oxo-ethylcarbamoyl]-methyl}-amide

[(S)-1-[(R)-1-({[(S)-2-(N'-Acetyl-hydrazino)-1-benzyl-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-butylcarbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester

Refernces