2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone

Base Information

• Chemical Name: 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone
• CAS No.: 857360-71-5
• Molecular Formula: C₁₄H₁₁Cl₂NO₂S
• Molecular Weight: 328.219
• Mol file: 857360-71-5.mol

Synonyms:

Chemical Property of 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone

There total 3 articles about 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-1-(5-phenylthiophen-2-yl)ethan-1-one (10531-43-8) → 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone (857360-71-5)

Guidance literature:

With chloroform; hexamethylenetetramine; Erwaermen des Reaktionsprodukts mit wss.-aethanol. Salzsaeure und Behandeln des Reaktionsprodukts mit Dichloracetylchlorid und Dimethylformamid;

DOI:10.1021/ja01616a044

Reference yield:

2-phenylthiophene (825-55-8) → 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone (857360-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium chloride; carbon disulfide

2: hexamethylenetetramine; chloroform / Erwaermen des Reaktionsprodukts mit wss.-aethanol. Salzsaeure und Behandeln des Reaktionsprodukts mit Dichloracetylchlorid und Dimethylformamid

With carbon disulfide; aluminium trichloride; chloroform; hexamethylenetetramine;

DOI:10.1021/ja01616a044

Reference yield:

dichloroacethyl chloride (79-36-7) + 2-amino-1-(5-phenyl-[2]thienyl)-ethanone; hydrochloride + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-(dichloroacetyl-amino)-1-(5-phenyl-[2]thienyl)-ethanone (857360-71-5)

Guidance literature:

DOI:10.1021/ja01616a044

upstream raw materials:

2-bromo-1-(5-phenylthiophen-2-yl)ethan-1-one

dichloroacethyl chloride

N,N-dimethyl-formamide

2-phenylthiophene