Technology Process of C15H24N5O8P
There total 4 articles about C15H24N5O8P which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tenofovir;
With
triethylamine;
In
1-methyl-pyrrolidin-2-one;
at 45 ℃;
chloromethyl isopropyl carbonate;
With
tetrabutylammomium bromide;
In
1-methyl-pyrrolidin-2-one;
at 45 - 50 ℃;
for 5.5h;
DOI:10.1021/op1001337
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / N,N-dimethyl-formamide / 120 °C
2.1: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C
3.1: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C
4.1: triethylamine / 1-methyl-pyrrolidin-2-one / 45 °C
4.2: 5.5 h / 45 - 50 °C
With
chloro-trimethyl-silane; magnesium 2-methylpropan-2-olate; triethylamine; sodium bromide; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/op1001337
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium 2-methylpropan-2-olate / 1-methyl-pyrrolidin-2-one / 70 - 74 °C
2.1: chloro-trimethyl-silane; sodium bromide / 1-methyl-pyrrolidin-2-one / 0 - 75 °C
3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 45 °C
3.2: 5.5 h / 45 - 50 °C
With
chloro-trimethyl-silane; magnesium 2-methylpropan-2-olate; triethylamine; sodium bromide;
In
1-methyl-pyrrolidin-2-one;
DOI:10.1021/op1001337
