Technology Process of (2S,3aS,6R,7aS)-methyl-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-6-hydroxyoctahydro-1H-indole-2-carboxylate
There total 10 articles about (2S,3aS,6R,7aS)-methyl-1-((2R,3S)-2-((R)-3-(4-(benzyloxy)phenyl)-2-((triisopropylsilyl)oxy)propanamido)-3-methylpentanoyl)-6-hydroxyoctahydro-1H-indole-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/ja309947n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 5%-palladium/activated carbon; hydrogen / 18 h / 20 °C / Inert atmosphere
2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere
With
5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja309947n
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluoroacetic acid; triethylsilane / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
2.1: dmap; 1H-imidazole / dichloromethane / 24 h / 20 °C / Inert atmosphere
3.1: water; lithium hydroxide / methanol; tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere
4.2: 40 h / 20 °C / Inert atmosphere
5.1: water; lithium hydroxide / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere
6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; triethylsilane; dmap; water; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja309947n