10a,12a-Dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione

Base Information Edit

Chemical Name:10a,12a-Dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione
CAS No.:1600-81-3
Molecular Formula:C₁₉H₂₇NO₂
Molecular Weight:301.429
Hs Code.:
NSC Number:136994
DSSTox Substance ID:DTXSID20300433
Mol file:1600-81-3.mol

Synonyms:10a,12a-dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione;1600-81-3;NSC136994;DTXSID20300433;NSC-136994

Suppliers and Price of 10a,12a-Dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 10a,12a-Dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione Edit

Chemical Property:

Vapor Pressure:3.51E-10mmHg at 25°C
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:301.204179104
Heavy Atom Count:22
Complexity:566

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC(=O)N4)C

Technology Process of 10a,12a-Dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione

There total 10 articles about 10a,12a-Dimethyl-1,3,4,4a,4b,5,6,9,10,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]quinoline-2,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.5%

: 7680-15-1
3β-hydroxy-13α-amino-13,17-seco-5-androsten-17-oic-13,17-lactam

: 1600-81-3
(10aR,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,9,10,10a,10b,11,12,12a-dodecahydronaphtho[2,1-f]quinoline-2,8(1H,3H)-dione

Guidance literature:: With cyclohexanone; aluminum isopropoxide; In 1,4-dioxane; toluene; for 5h; Reflux;
DOI:10.1016/j.ejmech.2012.06.026

Reference yield:

: 5615-38-3
(10R,13S)-17-(hydroxyimino)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]-phenanthren-3(2H)-one

: 1600-81-3
(10aR,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,9,10,10a,10b,11,12,12a-dodecahydronaphtho[2,1-f]quinoline-2,8(1H,3H)-dione

Guidance literature:: With pyridine; p-acetylaminobenzenesulfonyl chloride; und Behandeln des jeweiligen Reaktionsgemisches mit wss.Salzsaeure;
DOI:10.1021/ja01148a103

Reference yield:

: 853-23-6
prasterone acetate

: 1600-81-3
(10aR,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,9,10,10a,10b,11,12,12a-dodecahydronaphtho[2,1-f]quinoline-2,8(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 5 h / Reflux

2: thionyl chloride / 1,4-dioxane; benzene / 0.33 h / 15 - 20 °C

3: potassium hydroxide / methanol / 1.17 h / Reflux

4: cyclohexanone; aluminum isopropoxide / 1,4-dioxane; toluene / 5 h / Reflux

With thionyl chloride; hydroxylamine hydrochloride; sodium acetate; cyclohexanone; aluminum isopropoxide; potassium hydroxide; In 1,4-dioxane; methanol; ethanol; water; toluene; benzene; 2: Beckmann rearrangement / 4: Oppenauer oxidation;
DOI:10.1016/j.ejmech.2012.06.026