4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester

Base Information

• Chemical Name: 4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester
• CAS No.: 888970-51-2
• Molecular Formula: C₁₉H₂₇FO₂
• Molecular Weight: 306.421
• Mol file: 888970-51-2.mol

Synonyms:

Chemical Property of 4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester

There total 1 articles about 4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxycyclohexyl carboxylic acid ethyl ester (3618-04-0,75877-66-6,17159-80-7) + 2,3,4,5,6-pentamethylbenzyl chloride (484-65-1) → 4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester (888970-51-2) + (1R,3R)-3-Fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester + (1R,3S)-3-Fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester + trans-pentamethylbenzyl 4-fluorocyclohexanecarboxylate (223699-83-0)

Guidance literature:

4-hydroxycyclohexyl carboxylic acid ethyl ester; With pyridine; diethylamino-sulfur trifluoride; hydrogen fluoride; at 20 ℃; for 4h;

With sodium hydroxide; In water; at 20 ℃;

2,3,4,5,6-pentamethylbenzyl chloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2006.01.064

Reference yield:

4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester (888970-51-2) → 4-fluoro-cyclohexanecarbonyl chloride

Guidance literature:

4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester; With methoxybenzene; trifluoroacetic acid; at 20 ℃; for 0.0833333h;

With Dichloromethyl methyl ether; at 90 ℃; for 0.0833333h;

DOI:10.1016/j.bmc.2006.01.064

Reference yield:

4-fluoro-cyclohexanecarboxylic acid pentamethylphenylmethyl ester (888970-51-2) → cis-4-FCWAY

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; anisole / 0.08 h / 20 °C

1.2: dichloromethyl methyl ether / 0.08 h / 90 °C

2.1: 140 mg / triethylamine / CH₂Cl₂ / 2 h / 20 °C

With methoxybenzene; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmc.2006.01.064

upstream raw materials:

4-hydroxycyclohexyl carboxylic acid ethyl ester

2,3,4,5,6-pentamethylbenzyl chloride

Refernces