[2-(2-Methoxyphenyl)ethyl](methyl)amine

Base Information

• Chemical Name: [2-(2-Methoxyphenyl)ethyl](methyl)amine
• CAS No.: 104338-26-3
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• Hs Code.: 2922299090
• European Community (EC) Number: 888-059-6
• ChEMBL ID: CHEMBL4558958
• DSSTox Substance ID: DTXSID40517925
• Nikkaji Number: J579.369F
• Wikidata: Q82380213
• Mol file: 104338-26-3.mol

Synonyms:104338-26-3;[2-(2-methoxyphenyl)ethyl](methyl)amine;2-(2-methoxyphenyl)-N-methylethanamine;N-[2-(2-Methoxyphenyl)ethyl]-N-methylamine;[2-(2-Methoxy-phenyl)-ethyl]-methyl-amine;2-Methoxy-N-methyl-benzeneethanamine;MFCD00870494;2-(2-methoxyphenyl)-N-methylethan-1-amine;SCHEMBL681494;CHEMBL4558958;DTXSID40517925;UCAUHTUMXIYKFJ-UHFFFAOYSA-N;N-methyl-(2-methoxyphenyl)ethylamine;AKOS008069891;SB30351;N-methyl-2-(2-methoxyphenyl)-ethylamine;TS-00132;EN300-69868;C77728;F1911-1794;Z159528470

Chemical Property of [2-(2-Methoxyphenyl)ethyl](methyl)amine

Chemical Property:

• PSA: 21.26000
• LogP: 1.84800
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 116

Purity/Quality:

98% ^*data from raw suppliers

[2-(2-Methoxyphenyl)ethyl](methyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCC1=CC=CC=C1OC

Technology Process of [2-(2-Methoxyphenyl)ethyl](methyl)amine

There total 10 articles about [2-(2-Methoxyphenyl)ethyl](methyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(methoxycarbonyl)-2-(2-methoxyphenyl)ethylamine (258882-54-1) → 2-(2-methoxyphenyl)-N-methylethan-1-amine (104338-26-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1021/acs.jmedchem.0c01441

Reference yield: 87.0%

N-(t-Butyloxycarbonyl)-2-(2-methoxyphenyl)-ethylamine (131699-15-5) → 2-(2-methoxyphenyl)-N-methylethan-1-amine (104338-26-3)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran;

Reference yield:

2-methoxy-benzenepropanoic acid (6342-77-4) → 2-(2-methoxyphenyl)-N-methylethan-1-amine (104338-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 230 °C / Erhitzen im Ammoniak-Strom

2: sodium hypochlorite

3: benzaldehyde / anschliessend Behandeln des Reaktionsprodukts mit wss. Aethanol

With sodium hypochlorite; benzaldehyde;

DOI:10.1021/ja01348a024

upstream raw materials:

o-methoxy-2-phenylethylamine

methyl iodide

carbonic acid dimethyl ester

2-methoxy-benzenepropanoic acid

Downstream raw materials:

N-(2-methoxy-phenethyl)-N-methyl-urea

2-(2-methylamino-ethyl)-phenol

C₂₀H₂₂N₄O₂

Refernces

• 1、 Mock, Elliot D.,Kotsogianni, Ioli,Driever, Wouter P. F.,Fonseca, Carmen S.,Vooijs, Jelle M.,Den Dulk, Hans,Van Boeckel, Constant A. A.,Van Der Stelt, Mario. "Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D". . p. 481 - 515. Retrieved 2021/02/05.
• 2、 -. "INHIBITORS OF N-ACYLPHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D (NAPE-PLD)". . . Retrieved 2019/12/15.