N⁽¹⁾-benzyl-3,4-dihydroxypiperidine

Base Information

• Chemical Name: N⁽¹⁾-benzyl-3,4-dihydroxypiperidine
• CAS No.: 80477-53-8
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 80477-53-8.mol

Synonyms:

Chemical Property of N⁽¹⁾-benzyl-3,4-dihydroxypiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁽¹⁾-benzyl-3,4-dihydroxypiperidine

There total 3 articles about N⁽¹⁾-benzyl-3,4-dihydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N(1)-benzyl-3,4-dihydroxy-3,4-O-carbonylpiperidine → N(1)-benzyl-3,4-dihydroxypiperidine (80477-53-8,91564-35-1)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 16h;

DOI:10.1021/acs.joc.6b01107

Reference yield: 67.0%

1-benzyl-1,2,3,6-tetrahydropyridine (40240-12-8) → N(1)-benzyl-3,4-dihydroxypiperidine (80477-53-8,91564-35-1)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

DOI:10.1021/acs.joc.6b01107

Reference yield: 50.0%

1-phenylmethyl-1,2,3,6-tetrahydropyridine hydrochloride (80477-52-7) → N(1)-benzyl-3,4-dihydroxypiperidine (80477-53-8,91564-35-1)

Guidance literature:

With osmium(VIII) oxide; potassium chlorate; potassium carbonate; In water; at 70 - 80 ℃; for 10h;

DOI:10.1248/cpb.29.3026

upstream raw materials:

1-phenylmethyl-1,2,3,6-tetrahydropyridine hydrochloride

1-benzyl-1,2,3,6-tetrahydropyridine

Downstream raw materials:

1-benzylpiperidine-cis-diol acetonide

Refernces

• 1、 Takemura,Miki,Uono,Yoshimura,Kuroda,Suzuki. "Synthesis and selective activity of cholinergic agents with rigid skeletons. III". . p. 3026 - 3036. Retrieved 2007/10/02.