3,5-dichloro-2-iodopyridine

Base Information

• Chemical Name: 3,5-dichloro-2-iodopyridine
• CAS No.: 1214350-54-5
• Molecular Formula: C₅H₂Cl₂IN
• Molecular Weight: 273.888
• Mol file: 1214350-54-5.mol

Synonyms:

Chemical Property of 3,5-dichloro-2-iodopyridine

Chemical Property:

Purity/Quality:

3,5-Dichloro-2-iodopyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-2-iodopyridine

There total 1 articles about 3,5-dichloro-2-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

3,5-dichloropyridine (2457-47-8) → 3,5-dichloro-4-iodopyridine (343781-41-9) + 3,5-dichloro-2-iodopyridine (1214350-54-5)

Guidance literature:

3,5-dichloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl₂-N,N,N’,N’-tetramethylethylenediamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101993

Reference yield: 92.0%

3,5-dichloro-2-iodopyridine (1214350-54-5) + (trifluoromethyl)trimethylsilane (81290-20-2) → 3,5-dichloro-2-(trifluoromethyl)pyridine (7655-72-3)

Guidance literature:

(trifluoromethyl)trimethylsilane; With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 0.75h;

3,5-dichloro-2-iodopyridine; In 1-methyl-pyrrolidin-2-one; at 50 ℃;

Reference yield:

3,5-dichloro-2-iodopyridine (1214350-54-5) → l,3-dideoxy-2,4,6-tri-O-acetyl-1-(5-chloro-6-(trifluoromethyl)pyridin-3-ylthio)-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-α-D-galactopyranoside

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium fluoride; copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.75 h / 50 °C

1.2: 50 °C

2.1: sodium hydrogen sulfide / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 2 h / 50 °C

4.1: cesium fluoride; triethylamine; copper(l) iodide / acetonitrile / 2 h / 20 °C / Inert atmosphere

With sodium hydrogen sulfide; potassium fluoride; copper(l) iodide; sodium hydride; triethylamine; cesium fluoride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

3,5-dichloropyridine

Downstream raw materials:

3,5-dichloro-2-(trifluoromethyl)pyridine

Refernces