benzyl (S)-3-ethyldihydroorotate

Base Information

• Chemical Name: benzyl (S)-3-ethyldihydroorotate
• CAS No.: 124916-88-7
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.292
• Mol file: 124916-88-7.mol

Synonyms:

Chemical Property of benzyl (S)-3-ethyldihydroorotate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (S)-3-ethyldihydroorotate

There total 3 articles about benzyl (S)-3-ethyldihydroorotate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

ethanol (64-17-5) + benzyl (S)-dihydroorotate (103300-84-1) → benzyl (S)-3-ethyldihydroorotate (124916-88-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; for 4h; Heating;

DOI:10.1248/cpb.37.1764

Reference yield:

benzyl bromide (100-39-0) → benzyl (S)-3-ethyldihydroorotate (124916-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature

2: 59 percent / PPh₃, DEAD / dioxane / 4 h / Heating

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1764

Reference yield:

L-dihydroorotic acid (5988-19-2,6202-10-4) → benzyl (S)-3-ethyldihydroorotate (124916-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature

2: 59 percent / PPh₃, DEAD / dioxane / 4 h / Heating

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1764

upstream raw materials:

ethanol

benzyl (S)-dihydroorotate

benzyl bromide

L-dihydroorotic acid

Refernces