C₂₇H₃₅N₇O₃

Base Information

• Chemical Name: C₂₇H₃₅N₇O₃
• CAS No.: 1622905-88-7
• Molecular Formula: C₂₇H₃₅N₇O₃
• Molecular Weight: 505.62
• Mol file: 1622905-88-7.mol

Synonyms:

Chemical Property of C₂₇H₃₅N₇O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₅N₇O₃

There total 8 articles about C₂₇H₃₅N₇O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H18N4O (1536964-84-7) + C21H22N4O4 (1622880-57-2) → C27H35N7O3 (1622905-88-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2014.07.007

Reference yield:

methyl 6-amino-5-bromopyridine-3-carboxylate (180340-70-9) → C27H35N7O3 (1622905-88-7)

Guidance literature:

Multi-step reaction with 8 steps

1: toluene / 90 °C

2: triethylamine / tetrahydrofuran / 10 - 20 °C

3: tetrahydrofuran / 50 °C

4: sodium hydroxide / water / 1 h / 70 °C

5: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate / water; N,N-dimethyl-formamide / 3 h / 80 - 135 °C

6: hydrogenchloride / water

7: acetic acid / water; N,N-dimethyl-formamide / 18 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5: |Heck Reaction / 6: |Heck Reaction;

DOI:10.1016/j.bmcl.2014.07.007

Reference yield:

C14H14BrN3O4 (1622880-49-2) → C27H35N7O3 (1622905-88-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / water / 1 h / 70 °C

2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate / water; N,N-dimethyl-formamide / 3 h / 80 - 135 °C

3: hydrogenchloride / water

4: acetic acid / water; N,N-dimethyl-formamide / 18 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; 2: |Heck Reaction / 3: |Heck Reaction;

DOI:10.1016/j.bmcl.2014.07.007

upstream raw materials:

methyl 6-amino-5-bromopyridine-3-carboxylate

C₁₄H₁₄BrN₃O₄

C₁₃H₁₂BrN₃O₄

C₁₅H₁₅N₃O₅

Refernces