Technology Process of 2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonitril
There total 3 articles about 2,2-Dimethyl-5-phenyl-1,3-dioxolan-4-carbonitril which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahexylammonium bromide; potassium hydroxide / tetrahydrofuran / 22 h / 20 °C
2: Epoxide hydrolase Kau2 from Escherichia coli RE3 / aq. phosphate buffer; tert-butyl methyl ether / 27 °C / pH 7 / Resolution of racemate
3: Dowex? 50WX8 / acetone / 1.5 h
With
tetrahexylammonium bromide; potassium hydroxide;
In
tetrahydrofuran; aq. phosphate buffer; tert-butyl methyl ether; acetone;
DOI:10.1002/adsc.201401164
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Epoxide hydrolase Kau2 from Escherichia coli RE3 / aq. phosphate buffer; tert-butyl methyl ether / 27 °C / pH 7 / Resolution of racemate
2: Dowex? 50WX8 / acetone / 1.5 h
With
Epoxide hydrolase Kau2 from Escherichia coli RE3; Dowex 50WX8;
In
aq. phosphate buffer; tert-butyl methyl ether; acetone;
DOI:10.1002/adsc.201401164
