trans-α-phenyl-β-4-methylthiophenylacrylonitrile

Base Information

• Chemical Name: trans-α-phenyl-β-4-methylthiophenylacrylonitrile
• CAS No.: 28149-61-3
• Molecular Formula: C₁₆H₁₃NS
• Molecular Weight: 251.352
• Mol file: 28149-61-3.mol

Synonyms:

Chemical Property of trans-α-phenyl-β-4-methylthiophenylacrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-α-phenyl-β-4-methylthiophenylacrylonitrile

There total 4 articles about trans-α-phenyl-β-4-methylthiophenylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetonitrile (140-29-4) + 4-(Methylthio)benzaldehyde (3446-89-7) → trans-α-phenyl-β-4-methylthiophenylacrylonitrile (28149-61-3)

Guidance literature:

With sodium methylate;

Reference yield:

methyl-phenyl-thioether (100-68-5) → trans-α-phenyl-β-4-methylthiophenylacrylonitrile (28149-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid

2: hexamethylenetetramine; acetic acid / Erhitzen des Reaktionsprodukts mit H₂O

3: aq.-ethanolic KOH

With potassium hydroxide; hexamethylenetetramine; acetic acid;

DOI:10.1021/jo01137a005

Reference yield:

1-(chloromethyl)-4-methylthiobenzene (874-87-3) → trans-α-phenyl-β-4-methylthiophenylacrylonitrile (28149-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hexamethylenetetramine; acetic acid / Erhitzen des Reaktionsprodukts mit H₂O

2: aq.-ethanolic KOH

With potassium hydroxide; hexamethylenetetramine; acetic acid;

DOI:10.1021/jo01137a005

upstream raw materials:

phenylacetonitrile

4-(Methylthio)benzaldehyde

methyl-phenyl-thioether

1-(chloromethyl)-4-methylthiobenzene

Refernces