3-METHOXY-4-PROPOXY-BENZALDEHYDE

Base Information

• Chemical Name: 3-METHOXY-4-PROPOXY-BENZALDEHYDE
• CAS No.: 57695-98-4
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Mol file: 57695-98-4.mol

Synonyms:3-Methoxy-4-(n-propyloxy)benzaldehyde;3-Methoxy-4-propoxybenzaldehyde;

Chemical Property of 3-METHOXY-4-PROPOXY-BENZALDEHYDE

Chemical Property:

• Melting Point: 59-60 °C
• Boiling Point: 304.7 °C at 760 mmHg
• Flash Point: 129 °C
• PSA: 35.53000
• Density: 1.066 g/cm³
• LogP: 2.29650
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Methoxy-4-propoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxy-4-propoxybenzaldehyde is used in the synthesis of chalcone derivatives of benzo[b]furan as potential antibacterial agents.

Technology Process of 3-METHOXY-4-PROPOXY-BENZALDEHYDE

There total 10 articles about 3-METHOXY-4-PROPOXY-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

vanillin (121-33-5,8014-42-4) + propyl bromide (106-94-5) → 3-methoxy-4-n-propoxybenzaldehyde (57695-98-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 6h;

Reference yield:

vanillin (121-33-5,8014-42-4) → 3-methoxy-4-n-propoxybenzaldehyde (57695-98-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1007/s12039-016-1205-y

Reference yield:

2-methoxy-phenol (90-05-1) → 3-methoxy-4-n-propoxybenzaldehyde (57695-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / ethanol / 10 h / Reflux

2: trichlorophosphate / 19 h / 100 - 115 °C / Cooling with ice

With potassium carbonate; potassium iodide; trichlorophosphate; In ethanol; 2: |Vilsmeier-Haack Formylation;

DOI:10.1007/s11164-012-0804-6

upstream raw materials:

propyl bromide

1-iodo-propane

vanillin

2-methoxy-phenol

Downstream raw materials:

(3-methoxy-4-propoxyphenyl)methanol

C₁₁H₁₅NO₃

4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3-methoxy-4-propoxybenzyl)-1H-1,2,3-triazole

C₁₂H₁₈O₃

Refernces

• 1、 Cai, Hui,Gan, Xiuhai,Li, Shaoyuan,Song, Baoan,Wu, Qiong,Yuan, Ting. "Novel vanillin derivatives containing a 1,3,4-thiadiazole moiety as potential antibacterial agents". supporting information. . Retrieved 2020/03/24.
• 2、 -. "Senecio scandens derivative and application thereof in drugs". Paragraph 0019; 0032; 0034. . Retrieved 2018/08/04.