N-(3-FLUOROPHENYL)-2-NITROBENZENAMINE

Base Information

• Chemical Name: N-(3-FLUOROPHENYL)-2-NITROBENZENAMINE
• CAS No.: 322-77-0
• Molecular Formula: C12H9 F N2 O2
• Molecular Weight: 232.214
• Hs Code.: 2921440000
• Mol file: 322-77-0.mol

Synonyms:Diphenylamine,3'-fluoro-2-nitro- (8CI); NSC 93397

Chemical Property of N-(3-FLUOROPHENYL)-2-NITROBENZENAMINE

Chemical Property:

• Vapor Pressure: 8.09E-05mmHg at 25°C
• Boiling Point: 341.4°C at 760 mmHg
• Flash Point: 160.3°C
• PSA: 57.85000
• Density: 1.353g/cm³
• LogP: 4.07370

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-FLUOROPHENYL)-2-NITROBENZENAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-FLUOROPHENYL)-2-NITROBENZENAMINE

There total 2 articles about N-(3-FLUOROPHENYL)-2-NITROBENZENAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

meta-fluoroaniline (372-19-0) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → N-(3-fluorophenyl)-2-nitroaniline (322-77-0)

Guidance literature:

With potassium fluoride; potassium carbonate; for 0.333333h; Heating; microwave irradiation;

DOI:10.1055/s-2003-37530

Reference yield: 75.0%

meta-fluoroaniline (372-19-0) + 2-Chloronitrobenzene (88-73-3) → N-(3-fluorophenyl)-2-nitroaniline (322-77-0)

Guidance literature:

With potassium fluoride; potassium carbonate; for 0.333333h; Heating; microwave irradiation;

DOI:10.1055/s-2003-37530

Reference yield:

N-(3-fluorophenyl)-2-nitroaniline (322-77-0) → N-(3-fluorophenyl)-o-phenylenediamine (14207-66-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 2h; under 2068.65 Torr;

upstream raw materials:

meta-fluoroaniline

2-Chloronitrobenzene

ortho-nitrofluorobenzene

Downstream raw materials:

N-(3-fluorophenyl)-o-phenylenediamine

5-(3-fluorophenyl)-3-isopropylimino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

5-(3-fluorophenyl)-3-(4-tetrahydropyranyl)imino-2-(2-methoxy-3-pyridyl)amino-3,5-dihydrophenazine

Refernces

• 1、 Zhang, Aigui,Zhou, Jingya,Tao, Ke,Hou, Taiping,Jin, Hong. "Design, synthesis and antifungal evaluation of novel pyrazole carboxamides with diarylamines scaffold as potent succinate dehydrogenase inhibitors". supporting information. p. 3042 - 3045. Retrieved 2018/08/11.
• 2、 Zhang, Dongfeng,Liu, Yang,Zhang, Chunlin,Zhang, Hao,Wang, Bin,Xu, Jian,Fu, Lei,Yin, Dali,Cooper, Christopher B.,Ma, Zhenkun,Lu, Yu,Huang, Haihong. "Synthesis and biological evaluation of novel 2-methoxypyridylamino- substituted riminophenazine derivatives as antituberculosis agents". . p. 4380 - 4394. Retrieved 2014/05/20.