raltegravir tert-butylamine salt

Base Information

• Chemical Name: raltegravir tert-butylamine salt
• CAS No.: 1337990-94-9
• Molecular Formula: C₄H₁₁N*C₂₀H₂₁FN₆O₅
• Molecular Weight: 517.56
• Mol file: 1337990-94-9.mol

Synonyms:

Chemical Property of raltegravir tert-butylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of raltegravir tert-butylamine salt

There total 2 articles about raltegravir tert-butylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

raltegravir (518048-05-0) + tert-butylamine (75-64-9) → raltegravir tert-butylamine salt (1337990-94-9)

Guidance literature:

In ethyl acetate; at 20 - 50 ℃; for 72h; Product distribution / selectivity;

Reference yield:

raltegravir potassium → raltegravir tert-butylamine salt (1337990-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / pH 2

2: ethyl acetate / 72 h / 20 - 50 °C

With hydrogenchloride; In water; ethyl acetate;

upstream raw materials:

raltegravir

tert-butylamine

Refernces

• 1、 -. "RALTEGRAVIR SALTS AND CRYSTALLINE FORMS THEREOF". Page/Page column 25. . Retrieved 2011/10/13.