Technology Process of 4-(4-nitrobenzylidene)-2-(2-fluorophenyl)-5(4H)-oxazolone
There total 3 articles about 4-(4-nitrobenzylidene)-2-(2-fluorophenyl)-5(4H)-oxazolone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; sodium hydroxide / 2-methyltetrahydrofuran / 1 h / 25 - 28 °C
2: sodium acetate; acetic anhydride / 2-methyltetrahydrofuran / 4 h / Reflux
With
water; sodium acetate; acetic anhydride; sodium hydroxide;
In
2-methyltetrahydrofuran;
2: Erlenmeyer-Plochl reaction;
DOI:10.1021/op100032s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate / 2-methyltetrahydrofuran; water / 0.5 h / Cooling
1.2: 3 h / 10 °C / Cooling
2.1: water; sodium hydroxide / 2-methyltetrahydrofuran / 1 h / 25 - 28 °C
3.1: sodium acetate; acetic anhydride / 2-methyltetrahydrofuran / 4 h / Reflux
With
water; sodium acetate; acetic anhydride; sodium hydrogencarbonate; sodium hydroxide;
In
2-methyltetrahydrofuran; water;
1.2: Schotten-Baumann reaction / 3.1: Erlenmeyer-Plochl reaction;
DOI:10.1021/op100032s
- Guidance literature:
-
With
sodium acetate; acetic anhydride;
In
2-methyltetrahydrofuran;
for 4h;
Reflux;
DOI:10.1021/op100032s