Technology Process of Phenol, 5-fluoro-2,4-dimethoxy-3-methyl-
There total 6 articles about Phenol, 5-fluoro-2,4-dimethoxy-3-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
acetone;
for 1h;
Heating;
DOI:10.1021/jo00376a007
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 69 percent / Br2, CH3COONa, I2 / acetic acid / 24 h / 80 °C
2: 1.) m-CPBA, 2.) KOH / 1.) CH2Cl2, 3 h, RT, 2.) MeOH, 1 h, 0 deg C
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) 1 h
4: 1.) n-BuLi, 2.) FClO3 / 1.) Et2O, hexane, -75 deg C, 1 h, 2.) Et2O, hexane, -50 deg C, 1 h
5: 72 percent / 5percent HCl / acetone / 1 h / Heating
With
hydrogenchloride; potassium hydroxide; n-butyllithium; perchloryl fluoride; bromine; iodine; sodium acetate; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
In
acetic acid; acetone;
DOI:10.1021/jo00376a007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) m-CPBA, 2.) KOH / 1.) CH2Cl2, 3 h, RT, 2.) MeOH, 1 h, 0 deg C
2: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) 1 h
3: 1.) n-BuLi, 2.) FClO3 / 1.) Et2O, hexane, -75 deg C, 1 h, 2.) Et2O, hexane, -50 deg C, 1 h
4: 72 percent / 5percent HCl / acetone / 1 h / Heating
With
hydrogenchloride; potassium hydroxide; n-butyllithium; perchloryl fluoride; sodium hydride; 3-chloro-benzenecarboperoxoic acid;
In
acetone;
DOI:10.1021/jo00376a007
