1-benzyl-4-chloroperhydroazepine hydrochloride

Base Information

• Chemical Name: 1-benzyl-4-chloroperhydroazepine hydrochloride
• CAS No.: 109386-79-0
• Molecular Formula: C₁₃H₁₈ClN*ClH
• Molecular Weight: 260.207
• Mol file: 109386-79-0.mol

Synonyms:

Chemical Property of 1-benzyl-4-chloroperhydroazepine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-chloroperhydroazepine hydrochloride

There total 6 articles about 1-benzyl-4-chloroperhydroazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzyl-4-hydroxyhexahydro-1H-azepine (109162-29-0) → 1-benzyl-4-chloroperhydroazepine hydrochloride (109386-79-0)

Guidance literature:

In benzene; for 1h; Ambient temperature;

Reference yield:

3-benzylamino-propionic acid methyl ester (23574-01-8) → 1-benzyl-4-chloroperhydroazepine hydrochloride (109386-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / K₂CO₃ / CHCl₃ / 7.5 h / Heating

2: 1) C₂H₅OK, 2) HCl / 1) ethanol, xylene, reflux, 16 h; 2) ethanol.

3: 92 percent / K₂CO₃, sodium dihydridobis(2-methoxyethoxo)aluminate / benzene; toluene

4: 99 percent / benzene / 1 h / Ambient temperature

With hydrogenchloride; potassium ethoxide; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In chloroform; toluene; benzene;

Reference yield:

ethyl-3-benzylamino propionate (23583-21-3) → 1-benzyl-4-chloroperhydroazepine hydrochloride (109386-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / CHCl₃ / 7 h / Heating

2: 1) C₂H₅OK, 2) HCl / 1) ethanol, xylene, reflux; 2) ethanol.

3: 92 percent / K₂CO₃, sodium dihydridobis(2-methoxyethoxo)aluminate / benzene; toluene

4: 99 percent / benzene / 1 h / Ambient temperature

With hydrogenchloride; potassium ethoxide; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; In chloroform; toluene; benzene;

upstream raw materials:

1-benzyl-4-hydroxyhexahydro-1H-azepine

3-benzylamino-propionic acid methyl ester

ethyl-3-benzylamino propionate

ethyl 4-(N-benzyl-N-(2-ethoxycarbonylethyl))aminobutyrate

Refernces