p-methyl difluoronitroacetanilide

Base Information

• Chemical Name: p-methyl difluoronitroacetanilide
• CAS No.: 78659-26-4
• Molecular Formula: C₉H₈F₂N₂O₃
• Molecular Weight: 230.171
• Mol file: 78659-26-4.mol

Synonyms:

Chemical Property of p-methyl difluoronitroacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-methyl difluoronitroacetanilide

There total 2 articles about p-methyl difluoronitroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

difluoronitroacetyl chloride (336-94-7) + p-toluidine (106-49-0,12221-03-3) → p-methyl difluoronitroacetanilide (78659-26-4)

Guidance literature:

In diethyl ether; at 29.9 ℃; for 0.5h;

Reference yield: 30.0%

ethyl 2,2-difluoro-2-nitroacetate (680-69-3) + p-toluidine (106-49-0,12221-03-3) → p-methyl difluoronitroacetanilide (78659-26-4)

Guidance literature:

Heating;

DOI:10.1016/S0022-1139(00)82254-X

Reference yield: 50.0%

p-methyl difluoronitroacetanilide (78659-26-4) → p-methyl-N-difluoronitroethylaniline

Guidance literature:

With diborane; In tetrahydrofuran; RT, 2 h; reflux, 25 h;

DOI:10.1016/S0022-1139(00)82254-X

upstream raw materials:

difluoronitroacetyl chloride

p-toluidine

ethyl 2,2-difluoro-2-nitroacetate

Refernces

• 1、 Grigor'ev, V. Yu.,Solov'ev, V. P.,Dodcnov, M. V.,Brel', V. K.,Martynov, I. V.,Raevskii, O. A.. "ELECTRON-DONOR AND -ACCEPTOR FUNCTIONS OF PHYSIOLOGICALLY ACTIVE SUBSTANCES AND MODEL COMPOUNDS. XV. ELECTRON-ACCEPTOR POWER OF THE N-H GROUP IN 2,2-DIFLUORO-2-NITROACETANILIDES". . p. 746 - 750. Retrieved 2007/10/02.