Technology Process of 2,5-bis-benzyloxy-N-((R)-1-isopropylpiperidin-3-ylmethyl)nicotinamide
There total 9 articles about 2,5-bis-benzyloxy-N-((R)-1-isopropylpiperidin-3-ylmethyl)nicotinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / 1,1-dichloroethane / 0.17 h
2.1: triethylamine / 1,1-dichloroethane / 1 h
3.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.08 h
3.2: 2 h / 80 °C
With
1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydride; triethylamine;
In
1-methyl-pyrrolidin-2-one; 1,1-dichloroethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 67 h / 20 °C / Reflux
2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
3.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h / 20 °C
4.1: hydrazine hydrate / ethanol / 3 h / Reflux
5.1: triethylamine / 1,1-dichloroethane / 1 h
6.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.08 h
6.2: 2 h / 80 °C
With
sodium tris(acetoxy)borohydride; sodium hydride; hydrazine hydrate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,1-dichloroethane; ethanol; dichloromethane; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dichloromethane / 6 h / 0 - 20 °C
2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2.2: pH ~ 12
3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18.5 h / 0 - 20 °C
4.1: hydrazine hydrate / ethanol / 3 h / Reflux
5.1: triethylamine / 1,1-dichloroethane / 1 h
6.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.08 h
6.2: 2 h / 80 °C
With
sodium tris(acetoxy)borohydride; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,1-dichloroethane; ethanol; dichloromethane; mineral oil;
