3-Bromo-4'-fluorobiphenyl

Base Information

• Chemical Name: 3-Bromo-4'-fluorobiphenyl
• CAS No.: 10540-35-9
• Molecular Formula: C12H8BrF
• Molecular Weight: 251.098
• Hs Code.: 2903999090
• European Community (EC) Number: 690-430-0
• DSSTox Substance ID: DTXSID60373666
• Wikidata: Q82161942
• Mol file: 10540-35-9.mol

Synonyms:3-Bromo-4'-fluorobiphenyl;10540-35-9;1-bromo-3-(4-fluorophenyl)benzene;3-bromo-4'-fluoro-1,1'-biphenyl;3-BROMO-4'-FLUOROBIPHENY;3-BROMO-4/'-FLUOROBIPHENY;1,1'-Biphenyl, 3-bromo-4'-fluoro-;3-Bromo-4/'-fluorobiphenyl;SCHEMBL1736367;DTXSID60373666;3-Bromo-4'-fluorobiphenyl 97%;QATHBEJSFHQDCO-UHFFFAOYSA-N;AMY33052;AKOS023382883;FS-6093;CS-0060390

Chemical Property of 3-Bromo-4'-fluorobiphenyl

Chemical Property:

• Boiling Point: 298.0±15.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.433±0.06 g/cm3(Predicted)
• LogP: 4.25520
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 249.97934
• Heavy Atom Count: 14
• Complexity: 175

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-4''-fluorobiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Br)C2=CC=C(C=C2)F

Technology Process of 3-Bromo-4'-fluorobiphenyl

There total 5 articles about 3-Bromo-4'-fluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromobenzene (108-86-1,52753-63-6) + 4-fluorobenzenediazonium tetrafluoroborate (459-45-0) → 4-bromo-4'-fluorobiphenyl (398-21-0) + 3-(4-fluorophenyl)phenyl bromide (10540-35-9) + 2-bromo-4’-fluoro-1,1’-biphenyl (89346-54-3)

Guidance literature:

With potassium acetate; 18-crown-6 ether; for 1.5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo00183a021

Reference yield:

1,3-dibromobenzene (108-36-1) + 4-fluoroboronic acid (1765-93-1) → 3-(4-fluorophenyl)phenyl bromide (10540-35-9)

Guidance literature:

With sodium carbonate; In toluene;

Reference yield:

1,3-dibromobenzene (108-36-1) + 4-fluoroboronic acid (1765-93-1) + sodium carbonate (497-19-8) → 3-(4-fluorophenyl)phenyl bromide (10540-35-9)

Guidance literature:

tetrakis(triphenylphosphine)palladium ⁽⁰⁾; In water; N,N-dimethyl-formamide;

upstream raw materials:

bromobenzene

4-fluorobenzenediazonium tetrafluoroborate

N-(3'-bromo-biphenyl-4-yl)-acetamide

1,3-dibromobenzene

Downstream raw materials:

(4'-fluoro-[1,1'-biphenyl]-3-yl)boronic acid

1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-ethanol

Refernces

• 1、 -. "Novel imidazole derivatives, production method thereof and use thereof". . . Retrieved 2008/06/13.
• 2、 Beadle, James R.,Korzeniowsky, Stephen H.,Rosenberg, David E.,Garcia-Slanga, Blanche J.,Gokel, George W.. "Phase-Transfer-Catalyzed Gomberg-Bachmann Synthesis of Unsymmetrical Biarenes: A Survey of Catalysts and Substrates". . p. 1594 - 1603. Retrieved 2007/10/02.