C₁₅H₁₁BrF₂O₂

Base Information

• Chemical Name: C₁₅H₁₁BrF₂O₂
• CAS No.: 1361938-39-7
• Molecular Formula: C₁₅H₁₁BrF₂O₂
• Molecular Weight: 341.152
• Mol file: 1361938-39-7.mol

Synonyms:

Chemical Property of C₁₅H₁₁BrF₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁BrF₂O₂

There total 4 articles about C₁₅H₁₁BrF₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H11BrO3 (1361938-38-6) → C15H11BrF2O2 (1361938-39-7)

Guidance literature:

With difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

5-bromophthalide (64169-34-2) → C15H11BrF2O2 (1361938-39-7)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium hydroxide; water / 3 h / 20 °C

2: N,N-dimethyl-formamide / 20 °C

3: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1.5 h / Cooling with ice

4: difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride) / dichloromethane / 20 °C / Cooling with ice

With water; sulfur trioxide pyridine complex; difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride); triethylamine; lithium hydroxide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

4-bromo-2-(hydroxymethyl)benzoic acid (670256-21-0) → C15H11BrF2O2 (1361938-39-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 20 °C

2: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1.5 h / Cooling with ice

3: difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride) / dichloromethane / 20 °C / Cooling with ice

With sulfur trioxide pyridine complex; difluoro-4-morpholinylsulfonium tetrafluoroborate; triethylamine tris(hydrogen fluoride); triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

5-bromophthalide

4-bromo-2-(hydroxymethyl)benzoic acid

C₁₅H₁₃BrO₃

C₁₅H₁₁BrO₃

Downstream raw materials:

C₈H₅BrF₂O₂

Refernces