Technology Process of (S)-2-hydroxy-2-(p-tolyl)cyclopentanone
There total 4 articles about (S)-2-hydroxy-2-(p-tolyl)cyclopentanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane; C20H24Cl2Ti; triethylamine hydrochloride; zinc;
In
tetrahydrofuran; water;
at 22 ℃;
for 24h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201204469
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium carbonate / water / 12 - 15 h / Reflux
2: chloro-trimethyl-silane; C20H24Cl2Ti; triethylamine hydrochloride; zinc / tetrahydrofuran; water / 24 h / 22 °C / Inert atmosphere
With
chloro-trimethyl-silane; C20H24Cl2Ti; triethylamine hydrochloride; sodium carbonate; zinc;
In
tetrahydrofuran; water;
DOI:10.1002/anie.201204469
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / ethanol / 40 - 50 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: sodium carbonate / water / 12 - 15 h / Reflux
3.1: chloro-trimethyl-silane; C20H24Cl2Ti; triethylamine hydrochloride; zinc / tetrahydrofuran; water / 24 h / 22 °C / Inert atmosphere
With
chloro-trimethyl-silane; C20H24Cl2Ti; triethylamine hydrochloride; sodium hydride; sodium carbonate; zinc;
In
tetrahydrofuran; ethanol; water;
DOI:10.1002/anie.201204469