Technology Process of 5-(2'-deoxy-3',5'-di-O-toluoyl-β-D-ribofuranosyl)-1-<2-(4-nitrophenyl)ethyl>-1H-imidazole-2-carbonitrile
There total 7 articles about 5-(2'-deoxy-3',5'-di-O-toluoyl-β-D-ribofuranosyl)-1-<2-(4-nitrophenyl)ethyl>-1H-imidazole-2-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Raney nickel, NaH2PO2 / pyridine; acetic acid; H2O / 1.5 h / Ambient temperature
2: toluene-p-sulfonic acid monohydrate / CH2Cl2; acetone / 1) 0 deg C --> room temperature, 30 min; 2) room temperature
3: 1.) potassium tert-butoxide / 1) 1,2-dimethoxyethane, -35 deg C; 2) 1,2-dimethoxyethane, -35 deg C, 30 min
4: 42 percent / POCl3, Et3N / 1,2-dimethoxy-ethane / 1 h / -5 °C
5: sodium methoxide / 1,2-dimethoxy-ethane; methanol / 0.5 h
6: dimethylformamide / 10 h / 45 °C
With
sodium hypophosphite; potassium tert-butylate; sodium methylate; nickel; toluene-4-sulfonic acid; triethylamine; trichlorophosphate;
In
pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium methoxide / 1,2-dimethoxy-ethane; methanol / 0.5 h
2: dimethylformamide / 10 h / 45 °C
With
sodium methylate;
In
methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) potassium tert-butoxide / 1) 1,2-dimethoxyethane, -35 deg C; 2) 1,2-dimethoxyethane, -35 deg C, 30 min
2: 42 percent / POCl3, Et3N / 1,2-dimethoxy-ethane / 1 h / -5 °C
3: sodium methoxide / 1,2-dimethoxy-ethane; methanol / 0.5 h
4: dimethylformamide / 10 h / 45 °C
With
potassium tert-butylate; sodium methylate; triethylamine; trichlorophosphate;
In
methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide;