Isoxazole, 4-chloro-3,5-diphenyl-

Base Information

• Chemical Name: Isoxazole, 4-chloro-3,5-diphenyl-
• CAS No.: 10557-79-6
• Molecular Formula: C15H10ClNO
• Molecular Weight: 255.703
• Mol file: 10557-79-6.mol

Synonyms:

Chemical Property of Isoxazole, 4-chloro-3,5-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoxazole, 4-chloro-3,5-diphenyl-

There total 8 articles about Isoxazole, 4-chloro-3,5-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Z)-1,3-diphenylprop-2-yn-1-one O-methyl oxime (870127-38-1) → 4-chloro-3,5-diphenylisoxazole (10557-79-6)

Guidance literature:

With N-chloro-succinimide; chloro-trimethyl-silane; In nitromethane; at 20 ℃; for 1h; Solvent;

DOI:10.1039/c6ra09396e

Reference yield: 87.0%

3,5-diphehylisoxazole (2039-49-8) → 4-chloro-3,5-diphenylisoxazole (10557-79-6)

Guidance literature:

With nitrosylsulfuric acid; nitromethane; tetramethlyammonium chloride; at 20 ℃; for 1h; Reagent/catalyst;

DOI:10.1021/acs.joc.0c02106

Reference yield: 70.0%

1,2-diphenyl-cyclopropane (29881-14-9) → 4-chloro-3,5-diphenylisoxazole (10557-79-6)

Guidance literature:

1,2-diphenyl-cyclopropane; With nitrosylsulfuric acid; nitromethane; at 20 ℃; for 1h;

With tetramethlyammonium chloride;

DOI:10.1021/acs.joc.0c02106

upstream raw materials:

3,5-diphehylisoxazole

4-iodo-3,5-diphenylisoxazole

(Z)-1,3-diphenylprop-2-yn-1-one O-methyl oxime

1,3-diphenyl-2-propynone

Refernces

• 1、 Kaewsri, Wilailak,Thongsornkleeb, Charnsak,Tummatorn, Jumreang,Ruchirawat, Somsak. "Isomerizable (: E / Z)-alkynyl- O -methyl oximes employing TMSCl-NCS in chlorinative cyclization for the direct synthesis of 4-chloroisoxazoles". . p. 48666 - 48675. Retrieved 2016/06/09.
• 2、 Barluenga, Jose,Tomas, Miguel,Lopez, Luis Angel,Jardon, Jesus,Gotor, Vicente. "SYNTHESIS OF 5-AMINO-4-CHLORO-4,5-DIHYDROISOXAZOLES AND 4-CHLOROISOXAZOLES.". . p. 1763 - 1774. Retrieved 2007/10/02.