8-bromo-1-methoxy-isoquinoline

Base Information

• Chemical Name: 8-bromo-1-methoxy-isoquinoline
• CAS No.: 643069-25-4
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.084
• Mol file: 643069-25-4.mol

Synonyms:

Chemical Property of 8-bromo-1-methoxy-isoquinoline

Chemical Property:

• Boiling Point: 328.3±22.0 °C(Predicted)
• Density: 1.516±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-1-methoxyisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-bromo-1-methoxy-isoquinoline

There total 1 articles about 8-bromo-1-methoxy-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

methyl chloroformate (79-22-1) + 8-bromo-2-oxidoisoquinolin-2-ium (475994-58-2) → 8-bromo-1-methoxy-isoquinoline (643069-25-4)

Guidance literature:

With triethylamine; In methanol; at 0 ℃;

Reference yield: 34.0%

8-bromo-1-methoxy-isoquinoline (643069-25-4) + C12H22N2O4 (1229624-43-4,615568-57-5) → C22H29N3O5 (1229624-34-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.03.051

upstream raw materials:

methyl chloroformate

8-bromo-2-oxidoisoquinolin-2-ium

Downstream raw materials:

C₂₂H₂₉N₃O₅

Refernces