Technology Process of N-(3-bromophenyl)cinnamamide
There total 2 articles about N-(3-bromophenyl)cinnamamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
formic acid; hydroxylamine hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
acetonitrile;
at 80 ℃;
for 12h;
Overall yield = 68 %;
Schlenk technique;
DOI:10.1039/c3ob41218k
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: AlCl3 / chlorobenzene / 100 °C
2.1: POCl3 / 60 °C
3.1: n-BuLi / tetrahydrofuran / -78 °C
3.2: SO2(g) / diethyl ether
3.3: SO2Cl2 / hexane
4.1: Et3N / CH2Cl2
5.1: HCl / CH2Cl2
6.1: NH3 / methanol / Heating
7.1: H2; KOH / Pd/C / methanol; benzene / 50 °C
With
hydrogenchloride; potassium hydroxide; n-butyllithium; aluminium trichloride; ammonia; hydrogen; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; chlorobenzene; benzene;
1.1: Cyclization / 2.1: Chlorination / 3.1: Metallation / 3.2: Sulfonation / 3.3: Chlorination / 4.1: Sulfonylation / 5.1: Addition / 6.1: Substitution / 7.1: Dehalogenation;
DOI:10.1016/S0960-894X(99)00466-7