Technology Process of 7-chloro-5-(2-chlorophenyl)-4,5-dihydro-2-(2-dimethylaminoethylthio)-4-methyl-3H-1,4-benzodiazepine
There total 9 articles about 7-chloro-5-(2-chlorophenyl)-4,5-dihydro-2-(2-dimethylaminoethylthio)-4-methyl-3H-1,4-benzodiazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) 50percent NaH / 1.) mineral oil, DMF, r.t., 20 min; 2.) mineral oil, DMF, r.t., 1 h
2: 40 percent / 10 percent NaOH / H2O / 4 h / 50 °C / further reagent: HCl; further solvent: aq. DMSO; further temperatures and reaction times
3: 29.3 percent / 5percent HCl / methanol; H2O / 2.5 h / -20 °C
4: 92.8 percent / acetonitrile / 4 h / 60 °C
5: 59.5 percent / NaBH4 / ethanol / 4 h / Ambient temperature
6: 50.7 percent / P2S5 / CHCl3; pyridine / 1.) 30 min, room temperature; 2.) 3 h; 80 deg C
7: 10percent KOH / tetrahydrofuran / 2 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; tetraphosphorus decasulfide; sodium hydride;
In
tetrahydrofuran; pyridine; methanol; ethanol; chloroform; water; acetonitrile;
DOI:10.1248/cpb.30.1141
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 40 percent / 10 percent NaOH / H2O / 4 h / 50 °C / further reagent: HCl; further solvent: aq. DMSO; further temperatures and reaction times
2: 29.3 percent / 5percent HCl / methanol; H2O / 2.5 h / -20 °C
3: 92.8 percent / acetonitrile / 4 h / 60 °C
4: 59.5 percent / NaBH4 / ethanol / 4 h / Ambient temperature
5: 50.7 percent / P2S5 / CHCl3; pyridine / 1.) 30 min, room temperature; 2.) 3 h; 80 deg C
6: 10percent KOH / tetrahydrofuran / 2 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; tetraphosphorus decasulfide;
In
tetrahydrofuran; pyridine; methanol; ethanol; chloroform; water; acetonitrile;
DOI:10.1248/cpb.30.1141
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 92.7 percent / methanol / 0.5 h / 50 °C
2: 29.3 percent / 5percent HCl / methanol; H2O / 2.5 h / -20 °C
3: 92.8 percent / acetonitrile / 4 h / 60 °C
4: 59.5 percent / NaBH4 / ethanol / 4 h / Ambient temperature
5: 50.7 percent / P2S5 / CHCl3; pyridine / 1.) 30 min, room temperature; 2.) 3 h; 80 deg C
6: 10percent KOH / tetrahydrofuran / 2 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; tetraphosphorus decasulfide;
In
tetrahydrofuran; pyridine; methanol; ethanol; chloroform; water; acetonitrile;
DOI:10.1248/cpb.30.1141