6-O-desmethyl phenethyl-orvinol

Base Information

• Chemical Name: 6-O-desmethyl phenethyl-orvinol
• CAS No.: 1187551-67-2
• Molecular Formula: C₂₉H₃₃NO₄
• Molecular Weight: 459.585
• Mol file: 1187551-67-2.mol

Synonyms:

Chemical Property of 6-O-desmethyl phenethyl-orvinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-O-desmethyl phenethyl-orvinol

There total 1 articles about 6-O-desmethyl phenethyl-orvinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(20R)-phenethyl-orvinol (14521-98-3) → 6-O-desmethyl phenethyl-orvinol (1187551-67-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Reflux;

DOI:10.1021/jm500503k

Reference yield:

6-O-desmethyl phenethyl-orvinol (1187551-67-2) → 6-O-(2-fluoroethyl)phenethyl-orvinol (1613512-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane

2: sodium hydride / N,N-dimethyl-formamide; mineral oil

3: acetic acid / water / 0.08 h / 100 °C

With sodium hydride; acetic acid; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm500503k

Reference yield:

6-O-desmethyl phenethyl-orvinol (1187551-67-2) → 6-O-(2-fluoroethyl)-3-O-trityl-6-O-desmethyl phenethyl-orvinol (1613512-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: sodium hydride / N,N-dimethyl-formamide; mineral oil

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm500503k

upstream raw materials:

(20R)-phenethyl-orvinol

Downstream raw materials:

3-O-trityl-6-O-desmethyl phenethyl-orvinol

6-O-(2-fluoroethyl)-3-O-trityl-6-O-desmethyl phenethyl-orvinol

6-O-(2-fluoroethyl)phenethyl-orvinol

Refernces