(16α)-9-Fluoro-16,17,21-trihydroxy-pregna-1,4-diene-3,11,20-trione 16, 21-Diacetate

Base Information

• Chemical Name: (16α)-9-Fluoro-16,17,21-trihydroxy-pregna-1,4-diene-3,11,20-trione 16, 21-Diacetate
• CAS No.: 1868-22-0
• Molecular Formula: C₂₅H₂₉FO₈
• Molecular Weight: 476.499
• Mol file: 1868-22-0.mol

Synonyms:

Chemical Property of (16α)-9-Fluoro-16,17,21-trihydroxy-pregna-1,4-diene-3,11,20-trione 16, 21-Diacetate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

(16α)-9-Fluoro-16,17,21-trihydroxy-pregna-1,4-diene-3,11,20-trione16,21-Diacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A protected Triamcinolone (T767160) metabolite.

Technology Process of (16α)-9-Fluoro-16,17,21-trihydroxy-pregna-1,4-diene-3,11,20-trione 16, 21-Diacetate

There total 16 articles about (16α)-9-Fluoro-16,17,21-trihydroxy-pregna-1,4-diene-3,11,20-trione 16, 21-Diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triamcinolone diacetate (67-78-7) → 16α,21-diacetoxy-9-fluoro-17-hydroxy-pregna-1,4-diene-3,11,20-trione (1868-22-0)

Guidance literature:

With pyridine; chromium(VI) oxide;

DOI:10.1021/ja01516a044

Reference yield:

16α,21-diacetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione (98422-57-2,114417-77-5) → 16α,21-diacetoxy-9-fluoro-17-hydroxy-pregna-1,4-diene-3,11,20-trione (1868-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: CHCl₃; HF

2: mit Hilfe von Nocardia corallina

3: CrO₃; pyridine

With pyridine; chromium(VI) oxide; chloroform; hydrogen fluoride;

DOI:10.1021/ja01516a044

Reference yield:

11β,16α,17,21-tetrahydroxy-pregn-4-ene-3,20-dione (1171-81-9) → 16α,21-diacetoxy-9-fluoro-17-hydroxy-pregna-1,4-diene-3,11,20-trione (1868-22-0)

Guidance literature:

Multi-step reaction with 7 steps

1: mit Hilfe von Corynebacterium simplex oder Nocardia corallina

2: pyridine

3: SOCl₂; pyridine

4: aqueous HClO₄; dioxane

5: potassium acetate; ethanol

6: CHCl₃; HF

7: CrO₃; pyridine

With 1,4-dioxane; pyridine; chromium(VI) oxide; thionyl chloride; perchloric acid; ethanol; chloroform; hydrogen fluoride; potassium acetate;

DOI:10.1021/ja01516a044

upstream raw materials:

triamcinolone diacetate

16α,21-diacetoxy-9,11β-epoxy-17-hydroxy-9β-pregn-4-ene-3,20-dione

11β,16α,17,21-tetrahydroxy-pregn-4-ene-3,20-dione

16α,21-Diacetoxy-9α-fluoro-11β,17α-dihydroxpregn-4-ene-3,20-dione