1,2-Dimethylpyrrolidine

Base Information

• Chemical Name: 1,2-Dimethylpyrrolidine
• CAS No.: 765-48-0
• Molecular Formula: C₆H₁₃N
• Molecular Weight: 99.1759
• European Community (EC) Number: 212-149-0
• DSSTox Substance ID: DTXSID90903819
• Nikkaji Number: J193.134B
• Mol file: 765-48-0.mol

Synonyms:1,2-Dimethylpyrrolidine;765-48-0;EINECS 212-149-0;dimethylpyrrolidin;dimethylpyrrolidine;NoName_4578;1,2-dimethyl-pyrrolidine;Pyrrolidine, 1,2-dimethyl-;SCHEMBL10519137;DTXSID90903819;AKOS006273749;1-ETHYL-3-PIPERIDONEHYDROCHLORIDE

Chemical Property of 1,2-Dimethylpyrrolidine

Chemical Property:

• Vapor Pressure: 47.6mmHg at 25°C
• Refractive Index: 1.4268 (estimate)
• Boiling Point: 94.3°C at 760 mmHg
• PKA: 10.2(at 26℃)
• PSA: 3.24000
• Density: 0.828g/cm³
• LogP: 1.03840
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 99.104799419
• Heavy Atom Count: 7
• Complexity: 61.2

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1CCCN1C

Technology Process of 1,2-Dimethylpyrrolidine

There total 33 articles about 1,2-Dimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

benzyltrimethylsilane (770-09-2) + 3,4-dihydro-1,5-dimethyl-2H-pyrrolium perchlorate (2730-96-3) → 1,2-dimethylpyrrolidine (765-48-0,802254-03-1,802822-49-7) + 1,1'-(1,2-ethanediyl)bisbenzene (103-29-7) + 1,2-dimethyl-2-hydroxymethylpyrrolidine (100742-04-9) + 1,2-dimethyl-2-benzylpyrrolidine (100742-05-0)

Guidance literature:

In methanol; Irradiation;

DOI:10.1021/ja00333a066

Reference yield: 35.0%

3,4-dihydro-1,5-dimethyl-2H-pyrrolium perchlorate (2730-96-3) + toluene (108-88-3,15644-74-3,16713-13-6) → 1,2-dimethylpyrrolidine (765-48-0,802254-03-1,802822-49-7) + 1,1'-(1,2-ethanediyl)bisbenzene (103-29-7) + 1,2-dimethyl-2-hydroxymethylpyrrolidine (100742-04-9) + 1,2-dimethyl-2-benzylpyrrolidine (100742-05-0)

Guidance literature:

In methanol; Irradiation;

DOI:10.1021/ja00333a066

Reference yield: 7.0%

3,4-dihydro-1,5-dimethyl-2H-pyrrolium perchlorate (2730-96-3) + toluene (108-88-3,15644-74-3,16713-13-6) + acetonitrile (75-05-8,26809-02-9) → 1,2-dimethylpyrrolidine (765-48-0,802254-03-1,802822-49-7) + 1,1'-(1,2-ethanediyl)bisbenzene (103-29-7) + dihydrocinnamonitrile (645-59-0)

Guidance literature:

for 4h; Product distribution; Quantum yield; Irradiation; effect of arene;

DOI:10.1021/ja00243a028

upstream raw materials:

diazomethane

1-Methylpyrrolidine

methylene

2-methyltetrahydrofuran

Downstream raw materials:

4,4'-bis<(2-methylpyrrolidino)acetyl>biphenyl dimethiobromide

Refernces

• 1、 -. "IONIC LIQUID". Paragraph 0194; 0195. . Retrieved 2016/10/08.
• 2、 Gagné, Michel R.,Stern, Charlotte L.,Marks, Tobin J.. "Organolanthanide-catalyzed hydroamination. A kinetic, mechanistic, and diastereoselectivity study of the cyclization of N-unprotected amino olefins". . p. 275 - 294. Retrieved 2007/10/02.