Technology Process of N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(2H-indazol-2-yl)nicotinamide
There total 6 articles about N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(2H-indazol-2-yl)nicotinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C23H21N5O3;
With
dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
at 20 ℃;
for 0.5h;
Inert atmosphere;
With
dichloro-acetic acid;
at 20 ℃;
for 1.25h;
Inert atmosphere;
Cooling with ice;
DOI:10.1021/acs.jmedchem.7b00731
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; 18-crown-6 ether; potassium iodide / N,N-dimethyl-formamide / 130 °C / Inert atmosphere
2.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere
3.2: 5 - 20 °C / pH 10 / Inert atmosphere
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere
4.2: 1.25 h / 20 °C / Inert atmosphere; Cooling with ice
With
18-crown-6 ether; potassium carbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; sodium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: |Pfitzner-Moffatt Oxidation / 4.2: |Pfitzner-Moffatt Oxidation;
DOI:10.1021/acs.jmedchem.7b00731
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; 18-crown-6 ether; potassium iodide / N,N-dimethyl-formamide / 130 °C / Inert atmosphere
2.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere
3.2: 5 - 20 °C / pH 10 / Inert atmosphere
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere
4.2: 1.25 h / 20 °C / Inert atmosphere; Cooling with ice
With
18-crown-6 ether; potassium carbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; sodium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
4.1: |Pfitzner-Moffatt Oxidation / 4.2: |Pfitzner-Moffatt Oxidation;
DOI:10.1021/acs.jmedchem.7b00731