Technology Process of 4-<2-(oct-1-ynyl)phenyl>but-3-ynyl toluene-p-sulphonate
There total 10 articles about 4-<2-(oct-1-ynyl)phenyl>but-3-ynyl toluene-p-sulphonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
at 0 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 62 percent / triphenylphosphine, palladium(II) acetate, triethylamine / 110 °C
2: 77 percent / triphenylphosphine / 1.) dichloromethane, 5 deg C, 1 h, 2.) 20 deg C, overnight
3: 68 percent / potassium t-amylate / hexane / 1.) 0 - 20 deg C, 30 min, 2.) 20 deg C, overnight
4: 1.) butyl-lithium / 1.) THF, -78 deg C, 2 h, 2.) 48 h
5: 52.5 percent / pyridine / 48 h / 0 °C
With
pyridine; n-butyllithium; palladium diacetate; potassium 2-methylbutan-2-olate; triethylamine; triphenylphosphine;
In
hexane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 37 percent / tetrakis(triphenylphosphine)palladium(0) / tetrahydrofuran / 60 °C
2: 77 percent / triphenylphosphine / 1.) dichloromethane, 5 deg C, 1 h, 2.) 20 deg C, overnight
3: 68 percent / potassium t-amylate / hexane / 1.) 0 - 20 deg C, 30 min, 2.) 20 deg C, overnight
4: 1.) butyl-lithium / 1.) THF, -78 deg C, 2 h, 2.) 48 h
5: 52.5 percent / pyridine / 48 h / 0 °C
With
pyridine; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium 2-methylbutan-2-olate; triphenylphosphine;
In
tetrahydrofuran; hexane;
