N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide

Base Information

• Chemical Name: N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide
• CAS No.: 107953-97-9
• Molecular Formula: C₂₆H₃₇N₃O₇
• Molecular Weight: 503.596
• Mol file: 107953-97-9.mol

Synonyms:

Chemical Property of N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide

There total 11 articles about N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

methylamine hydrochloride (593-51-1) + N-(4-(2-methoxy-4-nitrophenoxy)-1-butyl)cycloheximide (107953-93-5) → N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide (107953-97-9)

Guidance literature:

With hydrogenchloride; borax; In ethanol; water; acetonitrile; for 2.5h; Ambient temperature; Irradiation; pH=9;

DOI:10.1016/S0040-4020(01)87564-5

Reference yield: 25.0%

cycloheximide (66-81-9,642-81-9,1154-57-0,3226-22-0,4630-75-5,5549-69-9,6258-25-9,6746-42-5,17280-60-3,17973-87-4,18006-33-2,29106-61-4,94130-62-8,94130-63-9,94799-82-3,95272-16-5,95272-17-6,95272-18-7) + 1-bromo-4-(2-methylamino-4-nitrophenoxy)butane (107954-02-9) → N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide (107953-97-9)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Heating; pH=9;

DOI:10.1016/S0040-4020(01)87564-5

Reference yield:

potassium 2-methoxy-4-nitrophenolate monohydrate (100200-99-5) → N-(4-(2-methylamino-4-nitrophenoxy))butylcycloheximide (107953-97-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / acetone / 48 h / Heating

2: 78 percent / sodium hydroxide / methanol; H₂O / 4 h / Ambient temperature; Irradiation

3: 25 percent / potassium carbonate / acetone / 24 h / Heating; pH=9

With sodium hydroxide; potassium carbonate; In methanol; water; acetone;

DOI:10.1016/S0040-4020(01)87564-5

upstream raw materials:

methylamine hydrochloride

N-(4-(2-methoxy-4-nitrophenoxy)-1-butyl)cycloheximide

cycloheximide

1-bromo-4-(2-methylamino-4-nitrophenoxy)butane

Refernces