Technology Process of (2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3S,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide
There total 10 articles about (2E)-3-[4-(buta-2,3-dien-1-yloxy)phenyl]-N-[(3S,6R,9S)-3,4,7-trimethyl-6-(1-methylethyl)-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]prop-2-enamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C
2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C
3: lithium hydroxide / tetrahydrofuran; water / 0 °C
4: palladium 10% on activated carbon; hydrogen / ethanol
5: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 51 h / 0 - 20 °C
6: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C
7: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere; Cooling with ice
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100437
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 51 h / 0 - 20 °C
2: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C
3: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere; Cooling with ice
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100437
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C
2: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / Inert atmosphere; Cooling with ice
With
hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100437