2'-hydroxy-6'-methoxychalcone epoxide

Base Information

• Chemical Name: 2'-hydroxy-6'-methoxychalcone epoxide
• CAS No.: 135746-09-7
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.285
• Mol file: 135746-09-7.mol

Synonyms:

Chemical Property of 2'-hydroxy-6'-methoxychalcone epoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-hydroxy-6'-methoxychalcone epoxide

There total 5 articles about 2'-hydroxy-6'-methoxychalcone epoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-methoxy-6'-tetrahydropyranyloxychalcone epoxide (136257-64-2) → 2'-hydroxy-6'-methoxychalcone epoxide (135746-09-7,136257-61-9)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; for 0.25h;

DOI:10.1016/S0040-4020(01)80960-1

Reference yield:

2,6-dihydroxylacetophenone (699-83-2) → 2'-hydroxy-6'-methoxychalcone epoxide (135746-09-7,136257-61-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 69 percent / p-TsOH / dioxane / 20 h

2: 94 percent / K₂CO₃ / acetone / 140 h / Heating

3: 77 percent / aq.KOH / methanol / 20 h / Ambient temperature

4: 93 percent / H₂O₂, 2 M aq.NaOH / methanol / 2 h / Ambient temperature

5: 100 percent / 2 M aq.H₂SO₄ / dioxane / 0.25 h

With potassium hydroxide; sodium hydroxide; sulfuric acid; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; methanol; acetone;

DOI:10.1016/S0040-4020(01)80960-1

Reference yield:

2-hydroxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]acetophenone (63854-17-1) → 2'-hydroxy-6'-methoxychalcone epoxide (135746-09-7,136257-61-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / acetone / 140 h / Heating

2: 77 percent / aq.KOH / methanol / 20 h / Ambient temperature

3: 93 percent / H₂O₂, 2 M aq.NaOH / methanol / 2 h / Ambient temperature

4: 100 percent / 2 M aq.H₂SO₄ / dioxane / 0.25 h

With potassium hydroxide; sodium hydroxide; sulfuric acid; dihydrogen peroxide; potassium carbonate; In 1,4-dioxane; methanol; acetone;

DOI:10.1016/S0040-4020(01)80960-1

upstream raw materials:

2'-methoxy-6'-tetrahydropyranyloxychalcone epoxide

2,6-dihydroxylacetophenone

2-hydroxy-6-[(tetrahydro-2H-pyran-2-yl)oxy]acetophenone

2'-methoxy-6'-tetrahydropyranyloxyacetophenone

Downstream raw materials:

3-hydroxy-5-methoxyflavanone

erythro-4-methoxyaurone hydrate

4-methoxybenzofuran-3(2H)-one

(Z)-2-benzylidene-4-methoxybenzofuran-3(2H)-one

Refernces