(Z)-3-(3,4,5-Trimethoxyphenyl)-2-propenal

Base Information

• Chemical Name: (Z)-3-(3,4,5-Trimethoxyphenyl)-2-propenal
• CAS No.: 71277-12-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 71277-12-8.mol

Synonyms:

Chemical Property of (Z)-3-(3,4,5-Trimethoxyphenyl)-2-propenal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-(3,4,5-Trimethoxyphenyl)-2-propenal

There total 34 articles about (Z)-3-(3,4,5-Trimethoxyphenyl)-2-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol (1504-56-9) → 3,4,5-trimethoxycinnamaldehyde (71277-13-9,34346-90-2,71277-12-8)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/cmdc.201700239

Reference yield: 85.0%

3-(3',4',5'-trimethoxyphenyl)propanal (121667-78-5) → 3,4,5-trimethoxycinnamaldehyde (71277-13-9,34346-90-2,71277-12-8)

Guidance literature:

With iron(III) chloride; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In chlorobenzene; at 120 ℃; for 10h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.1c00043

Reference yield: 80.0%

isoelemicin (487-12-7,5273-84-7,5273-85-8) → 3,4,5-trimethoxycinnamaldehyde (71277-13-9,34346-90-2,71277-12-8)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; Ambient temperature;

DOI:10.3891/acta.chem.scand.52-1177

upstream raw materials:

(E)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol

(Z)-3,3-Diethoxy-1-(3,4,5-trimethoxyphenyl)-1-propen

elemicin

isoelemicin

Downstream raw materials:

(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoic acid

(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl chloride

(E)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol

3-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enylidene]-furane-2,4(3H,5H)-dione

Refernces

• 1、 Ando, Kaori,Watanabe, Haruka,Zhu, Xiaoxian. "One-Pot Preparation of (E)-α,β-Unsaturated Aldehydes by a Julia-Kocienski Reaction of 2,2-Dimethoxyethyl PT Sulfone Followed by Acid Hydrolysis". . p. 6969 - 6973. Retrieved 2021/05/06.
• 2、 Killoran, Patrick M.,Rossington, Steven B.,Wilkinson, James A.,Hadfield, John A.. "Expanding the scope of the Babler–Dauben oxidation: 1,3-oxidative transposition of secondary allylic alcohols". . p. 3954 - 3957. Retrieved 2016/08/09.