Technology Process of (1R,2S)-1-(4-hydroxy-3-methoxyphenyl)-2-(4-((E)-3-hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenoxy)propane-1,3-diol
There total 9 articles about (1R,2S)-1-(4-hydroxy-3-methoxyphenyl)-2-(4-((E)-3-hydroxyprop-1-en-1-yl)-2,6-dimethoxyphenoxy)propane-1,3-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1039/c6ra22026f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / neat (no solvent) / 4 h / 20 °C
1.2: 3 h / 20 °C
2.1: lithium aluminium tetrahydride; benzyl chloride / tetrahydrofuran / 0 - 20 °C
3.1: potassium carbonate; potassium iodide / acetone / 0.25 h / 20 °C
3.2: 20 °C
4.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C
4.2: 2 h / 0 - 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
5.2: 1 h / Inert atmosphere
6.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; potassium carbonate; benzyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1039/c6ra22026f
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; potassium iodide / acetone / 0.25 h / 20 °C
1.2: 20 °C
2.1: 1H-imidazole / dichloromethane / 0.5 h / 0 °C
2.2: 2 h / 0 - 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
4.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
With
1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; potassium carbonate; potassium iodide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1039/c6ra22026f