4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide

Base Information

• Chemical Name: 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide
• CAS No.: 108122-70-9
• Molecular Formula: C₁₃H₁₂N₂OS
• Molecular Weight: 244.317
• Mol file: 108122-70-9.mol

Synonyms:

Chemical Property of 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide

There total 8 articles about 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(p-Acetamidophenyl)-2-nitropropen (18982-48-4) → 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide (108122-70-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 68 percent / Fe, FeCl₃, 12 N HCl / methanol; H₂O / 4 h / Heating

2: acetonitrile / 1.) RT, overnight, 2.) reflux, 1.5 h

3: CH₃ONa / dimethylformamide / 3 h / 100 °C

4: 54 percent / 85percent aq. H₃PO₄ / 12 h / Heating

5: NaNO₂, aq. HCl

6: CuCN, water / toluene / 2 h / 0 °C

7: 1.) H₂S, 2.) 1,2-ethanediamine / 1.) DMF, 40 min., 2.) DMF, RT, overnight

With hydrogenchloride; phosphoric acid; hydrogen sulfide; water; sodium methylate; iron(III) chloride; iron; ethylenediamine; sodium nitrite; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/jm00389a011

Reference yield:

1-(4-acetamidophenyl)propan-2-one (4173-84-6) → 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide (108122-70-9)

Guidance literature:

Multi-step reaction with 6 steps

1: acetonitrile / 1.) RT, overnight, 2.) reflux, 1.5 h

2: CH₃ONa / dimethylformamide / 3 h / 100 °C

3: 54 percent / 85percent aq. H₃PO₄ / 12 h / Heating

4: NaNO₂, aq. HCl

5: CuCN, water / toluene / 2 h / 0 °C

6: 1.) H₂S, 2.) 1,2-ethanediamine / 1.) DMF, 40 min., 2.) DMF, RT, overnight

With hydrogenchloride; phosphoric acid; hydrogen sulfide; water; sodium methylate; ethylenediamine; sodium nitrite; In N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/jm00389a011

Reference yield:

para-acetamidobenzaldehyde (122-85-0) → 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide (108122-70-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 52 percent / β-alanine / butan-1-ol / 9 h / Heating

2: 68 percent / Fe, FeCl₃, 12 N HCl / methanol; H₂O / 4 h / Heating

3: acetonitrile / 1.) RT, overnight, 2.) reflux, 1.5 h

4: CH₃ONa / dimethylformamide / 3 h / 100 °C

5: 54 percent / 85percent aq. H₃PO₄ / 12 h / Heating

6: NaNO₂, aq. HCl

7: CuCN, water / toluene / 2 h / 0 °C

8: 1.) H₂S, 2.) 1,2-ethanediamine / 1.) DMF, 40 min., 2.) DMF, RT, overnight

With hydrogenchloride; phosphoric acid; hydrogen sulfide; water; sodium methylate; iron(III) chloride; iron; ethylenediamine; sodium nitrite; 3-amino propanoic acid; In methanol; water; N,N-dimethyl-formamide; toluene; acetonitrile; butan-1-ol;

DOI:10.1021/jm00389a011

upstream raw materials:

4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzonitrile

1-(p-Acetamidophenyl)-2-nitropropen

1-(4-acetamidophenyl)propan-2-one

para-acetamidobenzaldehyde

Downstream raw materials:

5-<4-(4,5-dihydro-1H-imidazol-2-yl)phenyl>-6-methyl-2(2H)-pyridone

Refernces