Terazosin impurity

Base Information

• Chemical Name: Terazosin impurity
• CAS No.: 1260939-66-9
• Molecular Formula: C₁₉H₂₇N₅O₄
• Molecular Weight: 389.454
• Mol file: 1260939-66-9.mol

Synonyms:

Chemical Property of Terazosin impurity

Chemical Property:

• Boiling Point: 578.8±60.0 °C(Predicted)
• PKA: 6.53±0.50(Predicted)
• Density: 1.253±0.06 g/cm3(Predicted)

Purity/Quality:

99.0% Min ^*data from raw suppliers

tert-?Butyl4-?(4-?Amino-?6,?7-?dimethoxyquinazolin-?2-?yl)?piperazine-?1-?carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: tert-?Butyl 4-?(4-?Amino-?6,?7-?dimethoxyquinazolin-?2-?yl)?piperazine-?1-?carboxylate is an impurity in the synthesis of Terazosin (T105000), an α-1-adrenergicblocker related to prazosin.

Technology Process of Terazosin impurity

There total 1 articles about Terazosin impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6,7-dimethoxyquinazolin-4-amine (23680-84-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (1260939-66-9)

Guidance literature:

2-chloro-6,7-dimethoxyquinazolin-4-amine; 1-t-Butoxycarbonylpiperazine; With macroporous polymer-supported carbonate; In dimethyl sulfoxide; at 100 ℃;

With macroporous polymer-supported isocyanate; In dimethyl sulfoxide; at 60 ℃;

DOI:10.1016/j.tetlet.2006.02.047

Reference yield:

4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (1260939-66-9) → 4-amino-6,7-dimethoxy-2-piperazin-1-ylquinazoline (60547-97-9)

Guidance literature:

4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester; With macroporous polymer-supported-TsOH; In dichloromethane; at 20 ℃;

With ammonium hydroxide; In methanol;

DOI:10.1016/j.tetlet.2006.02.047

upstream raw materials:

2-chloro-6,7-dimethoxyquinazolin-4-amine

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

4-amino-6,7-dimethoxy-2-piperazin-1-ylquinazoline

Refernces